ATG16L1 antibody (N-Term)

Catalog No. ABIN2785621

The Rabbit Polyclonal anti-ATG16L1 antibody has been validated for WB and IHC. It is suitable to detect ATG16L1 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit and Guinea Pig.

Quick Overview for ATG16L1 antibody (N-Term) (ABIN2785621)

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG16L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ATG16L1 Antibody

Binding Specificity: N-Term

Sequence: QYNKLLEKSD LHSVLAQKLQ AEKHDVPNRH EISPGHDGTW NDNQLQEMAQ

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 91%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against ATG16L1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATG16L1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 588 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATG16L1

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Alternative Name: ATG16L1

Background: Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy (Mizushima et al., 2003 [PubMed 12665549]).[supplied by OMIM].
Alias Symbols: APG16L, ATG16L, FLJ00045, FLJ10035, FLJ10828, FLJ22677, IBD10, WDR30, ATG16A
Protein Interaction Partner: WIPI2, RB1CC1, DEDD2, TRAF3IP3, NOD2, TMEM59, TLR2, SUMO2, ATG13, ATG5, ULK1, UBC, TNK2, SYNPO2, ATG12, NOD1, WDFY3, APP, RAB33B, RAB35, RAB3D, RAB33A, HSPA4, FCGRT, CLTC, AP2M1, ELAVL1, MAP1LC3C, MAP1LC3B, ATG3, CCT2, CCT7, AGPS, GAN, CCT3, SNAPC4, ATG16
Protein Size: 588

Molecular Weight: 66 kDa

Gene ID: 55054

NCBI Accession: NM_017974, NP_060444

UniProt: Q676U5

Pathways: Autophagy