PHLDA1 antibody (C-Term)

Catalog No. ABIN2785898

The Rabbit Polyclonal anti-PHLDA1 antibody has been validated for WB. It is suitable to detect PHLDA1 in samples from Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit and Dog. There is 1 publication available.

Quick Overview for PHLDA1 antibody (C-Term) (ABIN2785898)

Target: PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLDA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PHLDA1 Antibody

Binding Specificity: C-Term

Sequence: LAVKSTRQKQ QHLVQQQPPS QPQPQPQLQP QPQPQPQPQP QPQSQPQPQP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PHLDA1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PHLDA1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 401 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PHLDA1 antibody (ABIN2785898)

Tsuda, Davis, Argani, Shukla, McGill, Nagai, Saito, Laé, Fisher, Ladanyi: "TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition." in: Cancer research, Vol. 67, Issue 3, pp. 919-29, (2007) (PubMed).

Target Details for PHLDA1

Target: PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1))

Alternative Name: PHLDA1

Background: PHLDA1 is an evolutionarily conserved proline-histidine rich nuclear protein. It may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.
Alias Symbols: DT1P1B11, MGC131738, PHRIP, TDAG51
Protein Interaction Partner: UBC, SUMO1, MDFI, EGFR, APP, DNAJB1, HSPB1, HSPA4, ELAVL1, KRTAP4-12, RPL14, PLSCR1, HSPA4L, EIF3D, PABPC4,
Protein Size: 401

Molecular Weight: 45 kDa

Gene ID: 22822

NCBI Accession: NM_007350, NP_031376

UniProt: Q8WV24