ORC6 antibody (N-Term)

Catalog No. ABIN2786007

This anti-ORC6 antibody is a Rabbit Polyclonal antibody detecting ORC6 in WB. Suitable for Human, Dog, Cow, Horse and Rabbit.

Quick Overview for ORC6 antibody (N-Term) (ABIN2786007)

Target: ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))

Reactivity: Human, Dog, Cow, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ORC6 Antibody

Binding Specificity: N-Term

Sequence: KAEEYLRLSR VKCVGLSART TETSSAVMCL DLAASWMKCP LDRAYLIKLS

Predicted Reactivity: Cow: 92%, Dog: 100%, Horse: 77%, Human: 100%, Rabbit: 85%

Characteristics: This is a rabbit polyclonal antibody against ORC6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ORC6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ORC6

Target: ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))

Alternative Name: ORC6

Background: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Alias Symbols: ORC6L
Protein Interaction Partner: LHX4, SPAG5, UBC, ORC3, CDC7, ORC4, MCM7, MCM6, MCM4, MCM2, CDC6, APP, ORC2, SUMO2, XRCC5, XRCC6, HMGA1, MCM5, TERF2, ORC5, DBF4, CDC45, RPA1,
Protein Size: 252

Molecular Weight: 28 kDa

Gene ID: 23594

NCBI Accession: NM_014321, NP_055136

UniProt: Q9Y5N6

Pathways: Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA