CALCOCO1 antibody (N-Term)

Catalog No. ABIN2787240

This Rabbit Polyclonal antibody specifically detects CALCOCO1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit and Cow.

Quick Overview for CALCOCO1 antibody (N-Term) (ABIN2787240)

Target: CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CALCOCO1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CALCOCO1 Antibody

Binding Specificity: N-Term

Sequence: ESTTDGSPIH TSVQFQASYL PKPGAQLYQF RYVNRQGQVC GQSPPFQFRE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CALCOCO1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CALCOCO1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 691 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CALCOCO1

Target: CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))

Alternative Name: CALCOCO1

Background: CALCOCO1 functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR).CALCOCO1 is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. CALCOCO1 is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. CALCOCO1 functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.
Alias Symbols: Cocoa, KIAA1536, PP13275, calphoglin
Protein Interaction Partner: CWF19L2, CEP19, FAM161A, TBC1D15, DUSP13, ISOC1, GABARAPL2, NDC80, UBC, GRIK2, APP, APTX, EP300, CTNNB1, NEDD4, HIST1H4A, HIST1H3A, PCBD1, TBC1D17, CTNNBL1, CYTH3, SH3GL3, CRYBA2, CREBBP, MAPK1, KRT15, IPP, FOSL1,
Protein Size: 691

Molecular Weight: 77 kDa

Gene ID: 57658

NCBI Accession: NM_020898, NP_065949

UniProt: Q9P1Z2

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Chromatin Binding