ACTR1A antibody (Middle Region)

Catalog No. ABIN2787670

This Rabbit Polyclonal antibody specifically detects ACTR1A in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for ACTR1A antibody (Middle Region) (ABIN2787670)

Target: ACTR1A (Alpha Centractin (ACTR1A))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACTR1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACTR1A Antibody

Binding Specificity: Middle Region

Sequence: AIKERACYLS INPQKDETLE TEKAQYYLPD GSTIEIGPSR FRAPELLFRP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against ACTR1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ACTR1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 376 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ACTR1A

Target: ACTR1A (Alpha Centractin (ACTR1A))

Alternative Name: ACTR1A

Background: ACTR1A is a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60 % identical at the amino acid level to conventional actin.This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60 % identical at the amino acid level to conventional actin. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ARP1, CTRN1
Protein Interaction Partner: HUWE1, SUMO2, UBC, NUP133, DCTN4, MYCBP, DCTN3, DCTN2, ACTR1B, LMNB1, COG3, ACTR10, SMURF1, RRS1, PSMD1, PSMC4, MYH9, MCM7, COPS5, CUL1, CUL3, SUMO1, Cep76, Actr1a, Dctn1, Capza1, HDAC6, SPTBN2, SPTBN1, NUMA1, BICD2,
Protein Size: 376

Molecular Weight: 41 kDa

Gene ID: 10121

NCBI Accession: NM_005736, NP_005727

UniProt: P61163

Pathways: M Phase