Glucose-6-Phosphate Dehydrogenase antibody (Middle Region)

Catalog No. ABIN2787697

This anti-Glucose-6-Phosphate Dehydrogenase antibody is a Rabbit Polyclonal antibody detecting Glucose-6-Phosphate Dehydrogenase in WB. Suitable for Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit and Sheep.

Quick Overview for Glucose-6-Phosphate Dehydrogenase antibody (Middle Region) (ABIN2787697)

Target: Glucose-6-Phosphate Dehydrogenase (G6PD)

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glucose-6-Phosphate Dehydrogenase antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Glucose-6-Phosphate Dehydrogenase Antibody

Binding Specificity: Middle Region

Sequence: VTKNIHESCM SQIGWNRIIV EKPFGRDLQS SDRLSNHISS LFREDQIYRI

Predicted Reactivity: Cow: 85%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 86%, Sheep: 83%

Characteristics: This is a rabbit polyclonal antibody against G6PD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human G6PD

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 515 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Glucose-6-Phosphate Dehydrogenase

Target: Glucose-6-Phosphate Dehydrogenase (G6PD)

Alternative Name: G6PD

Background: G6PD is a glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: G6PD1
Protein Interaction Partner: G6PD, SUMO2, UBC, MDM2, CKB, CAPN1, ALDH7A1, ZNF622, ZFYVE19, UBFD1, CNDP2, ISOC1, MAT2B, ERP44, YWHAQ, SLC9A3R1, YWHAZ, YWHAH, YWHAG, YWHAE, YWHAB, EIF4H, VCL, UBE2V1, TGM2, PPP1R2, PGD, PAK2, LDHB, SFN, GNS, GLA, GBP2, EIF5, BAG3, FN1, CCT4, HARS, SUMO4
Protein Size: 515

Molecular Weight: 57 kDa

Gene ID: 2539

NCBI Accession: NM_000402, NP_000393

UniProt: P11413

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones