Interleukin 17a antibody (N-Term)

Catalog No. ABIN2787948

This Rabbit Polyclonal antibody specifically detects Interleukin 17a in WB. It exhibits reactivity toward Human, Rat, Cow, Pig, Dog, Goat, Horse and Rabbit.

Quick Overview for Interleukin 17a antibody (N-Term) (ABIN2787948)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Reactivity: Human, Rat, Cow, Pig, Dog, Goat, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Interleukin 17a antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Interleukin 17a Antibody

Binding Specificity: N-Term

Sequence: MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN

Predicted Reactivity: Cow: 83%, Dog: 85%, Goat: 83%, Horse: 77%, Human: 100%, Pig: 83%, Rabbit: 92%, Rat: 75%

Characteristics: This is a rabbit polyclonal antibody against IL17A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human IL17A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 155 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Interleukin 17a

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Alternative Name: IL17A

Background: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Alias Symbols: CTLA8, IL-17, IL-17A, IL17
Protein Interaction Partner: DPH2, TRAF3IP2, TRAF6, IL17RA, IL17A,
Protein Size: 155

Molecular Weight: 15 kDa

Gene ID: 3605

NCBI Accession: NM_002190, NP_002181

UniProt: Q16552