SH2D1A antibody (C-Term)

Catalog No. ABIN2788421

The Rabbit Polyclonal anti-SH2D1A antibody has been validated for WB. It is suitable to detect SH2D1A in samples from Human, Rat, Cow, Pig and Horse.

Quick Overview for SH2D1A antibody (C-Term) (ABIN2788421)

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reactivity: Human, Rat, Cow, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH2D1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SH2D1A Antibody

Binding Specificity: C-Term

Sequence: YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL

Predicted Reactivity: Cow: 86%, Horse: 92%, Human: 100%, Pig: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SH2D1A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 128 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Alternative Name: SH2D1A

Background: SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A
Protein Interaction Partner: LHX4, TNK2, UBC, LYN, MAPK11, MAPK1, ERBB3, EGFR, MAPK14, CD244, ELAVL1, SLAMF7, SLAMF6, ARHGEF7, CD84, SLAMF1, DOK1, FYB, LY9, ARHGEF6, LCK, FYN, GRB2,
Protein Size: 128

Molecular Weight: 14 kDa

Gene ID: 4068

NCBI Accession: NM_002351, NP_002342

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process