CDK14 antibody (C-Term)

Catalog No. ABIN2788962

The Rabbit Polyclonal anti-CDK14 antibody has been validated for WB. It is suitable to detect CDK14 in samples from Human, Mouse, Rat, Dog, Pig, Guinea Pig, Horse and Rabbit.

Quick Overview for CDK14 antibody (C-Term) (ABIN2788962)

Target: CDK14 (Cyclin-Dependent Kinase 14 (CDK14))

Reactivity: Human, Mouse, Rat, Dog, Pig, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDK14 Antibody

Binding Specificity: C-Term

Sequence: SDLPPRLWEL TDMSSIFTVP NVRLQPEAGE SMRAFGKNNS YGKSLSNSKH

Predicted Reactivity: Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Cdk14. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 469 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDK14

Target: CDK14 (Cyclin-Dependent Kinase 14 (CDK14))

Alternative Name: Cdk14

Background: Cdk14 is a Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Cdk14 acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Cdk14 acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. Cdk14 may also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
Alias Symbols: Pftk1, mKIAA0834
Protein Interaction Partner: SMURF1, TGFBR1, BMPR1B, ACVR1,
Protein Size: 469

Molecular Weight: 53 kDa

Gene ID: 18647

NCBI Accession: NM_011074, NP_035204

UniProt: O35495