ORC3 antibody (C-Term)

Catalog No. ABIN2789071

Product Details anti-ORC3 Antibody

Target: ORC3 (Origin Recognition Complex, Subunit 3 (ORC3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Cow, Dog, Rat, Pig, Rabbit, Zebrafish (Danio rerio), Saccharomyces cerevisiae, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORC3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VVTAAEKMDA NSATSEEMNE IIHARFIRAV SELELLGFIK PTKQKTDHVA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against ORC3L. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 712 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ORC3

Target: ORC3 (Origin Recognition Complex, Subunit 3 (ORC3))

Alternative Name: ORC3L (ORC3 Products)

Background: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
Alias Symbols: LAT, LATHEO, ORC3, ORC3L
Protein Interaction Partner: ORC5, ORC4, ORC1, MCM7, CDC6, MCM10, ORC6, CCNE2, CDC45, LRWD1, ORC2, APP, SUMO2, XRCC5, UBC, XRCC6, ZBP1, DBF4, ORC3, MCM5, CDK4, TERF2, BRCA1, MCM4,
Protein Size: 712

Molecular Weight: 82 kDa

Gene ID: 23595

NCBI Accession: NM_181837, NP_862820

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Feeding Behaviour, Synthesis of DNA