CTPS2 antibody (N-Term)

Catalog No. ABIN2789147

This Rabbit Polyclonal antibody specifically detects CTPS2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Cow, Pig, Rabbit, Zebrafish (Danio rerio) and Guinea Pig.

Quick Overview for CTPS2 antibody (N-Term) (ABIN2789147)

Target: CTPS2 (CTP Synthase II (CTPS2))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Pig, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTPS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CTPS2 Antibody

Binding Specificity: N-Term

Sequence: AKRENFCNIH VSLVPQLSAT GEQKTKPTQN SVRALRGLGL SPDLIVCRSS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CTPS2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 586 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CTPS2

Target: CTPS2 (CTP Synthase II (CTPS2))

Alternative Name: CTPS2

Background: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
Alias Symbols: DKFZp686C17207, FLJ43358, MGC32997
Protein Interaction Partner: CTPS2, SPG21, RNF2, LRSAM1, EHD4, EHD1, PLIN3, MTMR2, WARS, PRKDC, NUCB1, METTL1, KTN1, HSF1, GTF2I, DHPS, RPL37A, RPL23A, FGFR1, CTBP2, UBC, SUMO2, OTUD5,
Protein Size: 586

Molecular Weight: 64 kDa

Gene ID: 56474

NCBI Accession: NM_175859, NP_787055

UniProt: Q9NRF8

Pathways: Ribonucleoside Biosynthetic Process