SIK2 antibody (N-Term)

Catalog No. ABIN2789222

This anti-SIK2 antibody is a Rabbit Polyclonal antibody detecting SIK2 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit and Horse.

Quick Overview for SIK2 antibody (N-Term) (ABIN2789222)

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIK2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIK2 Antibody

Binding Specificity: N-Term

Sequence: VLYPQEQENE PSIGEFNEQV LRLMHSLGID QQKTIESLQN KSYNHFAAIY

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SIK2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 926 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SIK2

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Alternative Name: SIK2

Background: SIK2 phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. It inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Alias Symbols: DKFZp434K1115, KIAA0781, LOH11CR1I, QIK, SNF1LK2
Protein Interaction Partner: GABARAPL2, YWHAZ, YWHAE, VCP, HSPA4, HDAC5, CEP250, UBC, APP, BMH1, CRTC2, YWHAQ, PRKAA1, IRS1,
Protein Size: 926

Molecular Weight: 102 kDa

Gene ID: 23235

NCBI Accession: NM_015191, NP_056006

UniProt: Q9H0K1