WISP2 antibody (C-Term)

Catalog No. ABIN2789751

The Rabbit Polyclonal anti-WISP2 antibody has been validated for WB. It is suitable to detect WISP2 in samples from Human, Rat, Dog, Horse and Pig.

Quick Overview for WISP2 antibody (C-Term) (ABIN2789751)

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Reactivity: Human, Rat, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WISP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WISP2 Antibody

Binding Specificity: C-Term

Sequence: WGPCSTTCGL GMATRVSNQN RFCRLETQRR LCLSRPCPPS RGRSPQNSAF

Predicted Reactivity: Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against WISP2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 250 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for WISP2

Target: WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))

Alternative Name: WISP2

Background: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Alias Symbols: CCN5, CT58, CTGF-L
Protein Interaction Partner: HDAC3, HDAC1, IGF1R, IGF2R,
Protein Size: 250

Molecular Weight: 24 kDa

Gene ID: 8839

NCBI Accession: NM_003881, NP_003872

UniProt: O76076

Pathways: WNT Signaling, Growth Factor Binding