DMGDH antibody (Middle Region)

Catalog No. ABIN2789895

The Rabbit Polyclonal anti-DMGDH antibody has been validated for WB. It is suitable to detect DMGDH in samples from Human, Mouse, Rat, Pig, Horse, Rabbit, Zebrafish (Danio rerio), Cow, Dog and Guinea Pig.

Quick Overview for DMGDH antibody (Middle Region) (ABIN2789895)

Target: DMGDH (Dimethylglycine Dehydrogenase (DMGDH))

Reactivity: Human, Mouse, Rat, Pig, Horse, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMGDH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DMGDH Antibody

Binding Specificity: Middle Region

Sequence: SELHDLRWIE EAAFRGGYDV EIQNITDEFG VLGVAGPYAR RVLQKLTSE

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against Dmgdh. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse DMGDH

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DMGDH

Target: DMGDH (Dimethylglycine Dehydrogenase (DMGDH))

Alternative Name: Dmgdh

Background: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants.
Alias Symbols: DMGDHD, ME2GLYDH
Protein Size: 869

Molecular Weight: 93 kDa

Gene ID: 29958

NCBI Accession: NM_013391, NP_037523

UniProt: Q9UI17