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MOB1A antibody (C-Term)

This Rabbit Polyclonal antibody specifically detects MOB1A in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Dog and Zebrafish (Danio rerio).
Catalog No. ABIN2790218

Quick Overview for MOB1A antibody (C-Term) (ABIN2790218)

Target

See all MOB1A (MOBKL1B) Antibodies
MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Reactivity

  • 31
  • 14
  • 11
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Dog, Zebrafish (Danio rerio)

Host

  • 28
  • 3
Rabbit

Clonality

  • 28
  • 3
Polyclonal

Conjugate

  • 20
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This MOB1A antibody is un-conjugated

Application

  • 18
  • 15
  • 9
  • 8
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 7
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term

    Sequence

    FDSVMQLQEE AHLNTSFKHF IFFVQEFNLI DRRELAPLQE LIEKLGSKDR

    Predicted Reactivity

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

    Characteristics

    This is a rabbit polyclonal antibody against MOB1A. It was validated on Western Blot.

    Purification

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the C-terminal region of Human MOB1A
  • Application Notes

    Optimal working dilutions should be determined experimentally by the investigator.

    Comment

    Antigen size: 216 AA

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

    Alternative Name

    MOB1A

    Background

    MOB1A is an activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MOB1A stimulates the kinase activity of STK38 and STK38L. MOB1A acts cooperatively with STK3/MST2 to activate STK38.
    Alias Symbols: C2orf6, FLJ10788, FLJ11595, MATS1, MOB1, MOBK1B, Mob4B, MOBKL1B
    Protein Interaction Partner: FAM9B, CMTM3, SEPT3, FAM118A, KANK2, TDO2, UBC, HECW2, ANKRD52, AMOT, ANKRD44, DOCK7, LRCH3, RASSF5, DOCK8, MOB2, SAV1, LRCH2, DOCK6, THOC2, PPP6R3, CRLF3, IPO11, LATS2, ANKRD28, LRCH1, STK38L, PPP6R1, RASSF2, PPP6R2, LATS1, YWHAH, STK4, STK3, PTPN14, PPP
    Protein Size: 216

    Molecular Weight

    25 kDa

    Gene ID

    55233

    NCBI Accession

    NM_018221, NP_060691

    UniProt

    Q9H8S9
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