BCL2A1 antibody (C-Term)

Catalog No. ABIN2792231

Product Details anti-BCL2A1 Antibody

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Binding Specificity: C-Term

Reactivity: Rat, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2A1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FIMNNTGEWI RQNGGWENGF VKKFEPKSGW MTFLEVTGKI CEMLSLLKQY

Predicted Reactivity: Dog: 90%, Pig: 85%, Rat: 78%

Characteristics: This is a rabbit polyclonal antibody against BCL2A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human BCL2A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 175 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BCL2A1

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Alternative Name: BCL2A1 (BCL2A1 Products)

Background: BCL2A1s a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
Alias Symbols: GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5
Protein Interaction Partner: FAM9B, NR4A1, BIK, BAK1, APP, HAT1, BBC3, PMAIP1, BOK, BCL2L11, HRK, BAD, BID, BAX, GRB2, BMF,
Protein Size: 175

Molecular Weight: 20 kDa

Gene ID: 597

NCBI Accession: NM_004049, NP_004040

UniProt: Q16548