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SGOL2 antibody (Shugoshin-Like 2) (AA 391-419) Primary Antibody

SGOL2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2795993
$500.50
Plus shipping costs $45.00
400 μL
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Delivery in 6 to 8 Business Days
  • Target
    SGOL2
    Binding Specificity
    • 15
    • 9
    • 8
    • 1
    • 1
    • 1
    • 1
    AA 391-419, Center
    Reactivity
    • 22
    • 1
    Human
    Host
    • 22
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SGOL2 antibody is un-conjugated
    Application
    • 17
    • 17
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit Anti-Human SGOL2 (Center) Antibody
    Immunogen
    This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.
    Isotype
    Ig Fraction
  • Application Notes
    Western Blot
    Recommended Dilutions
    WB: 1:1000SGOL2 Antibody (Center) .
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Storage
    4 °C,-20 °C
    Storage Comment
    2-8°C (short-term), -20°C (long-term)
  • Target
    SGOL2
    Alternative Name
    SGOL2 (SGOL2 Antibody Abstract)
    Synonyms
    SGO2, TRIPIN, 1110007N04Rik, 4932411A20Rik, 5730576N04Rik, AU018846, AV008062, D1Ertd8e, Tripin, shugoshin 2, shugoshin 2A, SGO2, Sgo2a
    Background

    Target Description: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

    Gene Symbol: SGOL2

    Molecular Weight
    144739 Da
    Gene ID
    151246
    UniProt
    Q562F6
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