SGOL2 Products
(Shugoshin-Like 2 (SGOL2))
Categories
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
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Featured SGOL2 Categories
SGOL2 Antibodies
High quality antibodies with extensive validation data.
Recommended SGOL2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (5)
- (1)
Cat. No.
ABIN1881800
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC (p), IF
Validations
- (2)
Cat. No.
ABIN5587828
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
Cat. No.
ABIN7188086
Quantity
100 μg
Datasheet
Datasheet
Recommended SGOL2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3095378
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3135963
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SGOL2 products
: "The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL)." in: Frontiers in oncology, Vol. 9, pp. 429, (2019) (PubMed).: "Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis." in: Oncogene, Vol. 32, Issue 24, pp. 2973-83, (2013) (PubMed).
: "Potential role of meiosis proteins in melanoma chromosomal instability." in: Journal of skin cancer, Vol. 2013, pp. 190109, (2013) (PubMed).
: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." in: Genes & development, Vol. 24, Issue 19, pp. 2169-79, (2010) (PubMed).
: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).
: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." in: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, (2008) (PubMed).
: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." in: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, (2007) (PubMed).
: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." in: Nature, Vol. 441, Issue 7089, pp. 46-52, (2006) (PubMed).
Synonyms and alternative names related to SGOL2
shugoshin 2 (SGO2), shugoshin 2A (Sgo2a), 1110007N04Rik, 4932411A20Rik, 5730576N04Rik, AU018846, AV008062, D1Ertd8e, SGO2, TRIPIN, TripinProtein level used designations for SGOL2
- shugoshin-2
- shugoshin-like 2
- sgo2
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