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SGOL2 antibody (Shugoshin-Like 2) (AA 391-419) Primary Antibody

SGOL2 Reactivity: Human WB Host: Rabbit Polyclonal RB42663 unconjugated
Pubmed (5)
Catalog No. ABIN1881800
$423.50
Plus shipping costs $45.00
400 μL ABIN1881800
400 μL ABIN1881800
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  • Target
    SGOL2
    Binding Specificity
    • 15
    • 9
    • 8
    • 1
    • 1
    • 1
    • 1
    AA 391-419
    Reactivity
    • 21
    • 1
    Human
    Host
    • 21
    Rabbit
    Clonality
    • 21
    Polyclonal
    Conjugate
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SGOL2 antibody is un-conjugated
    Application
    • 17
    • 16
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.
    Clone
    RB42663
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Tanno, Kitajima, Honda, Ando, Ishiguro, Watanabe: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." in: Genes & development, Vol. 24, Issue 19, pp. 2169-79, 2010 (PubMed).

    Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, 2009 (PubMed).

    Lee, Kitajima, Tanno, Yoshida, Morita, Miyano, Miyake, Watanabe: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." in: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, 2008 (PubMed).

    Huang, Feng, Famulski, Rattner, Liu, Kao, Muschel, Chan, Yen: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." in: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, 2007 (PubMed).

    Kitajima, Sakuno, Ishiguro, Iemura, Natsume, Kawashima, Watanabe: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." in: Nature, Vol. 441, Issue 7089, pp. 46-52, 2006 (PubMed).

  • Target
    SGOL2
    Alternative Name
    SGOL2 (SGOL2 Antibody Abstract)
    Synonyms
    SGO2, TRIPIN, 1110007N04Rik, 4932411A20Rik, 5730576N04Rik, AU018846, AV008062, D1Ertd8e, Tripin, shugoshin 2, shugoshin 2A, SGO2, Sgo2a
    Background
    Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
    Molecular Weight
    144739
    NCBI Accession
    NP_001153518, NP_689737
    UniProt
    Q562F6
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