USP2 antibody (N-Term)

Catalog No. ABIN2796342

This anti-USP2 antibody is a Rabbit Polyclonal antibody detecting USP2 in WB, IHC and ISt. Suitable for Human.

Quick Overview for USP2 antibody (N-Term) (ABIN2796342)

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunostaining (ISt)

Product Details anti-USP2 Antibody

Binding Specificity: AA 71-101, N-Term

Purpose: Rabbit Anti-Human USP2 (N-term) Antibody

Immunogen: This USP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-101 amino acids from the N-terminal region of human USP2.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50Western blot analysis of USP2 Antibody (N-term) with the USP2 gene.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.0 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for USP2

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Alternative Name: USP2

Background:

Target Description: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Gene Symbol: USP2

Molecular Weight: 68072 Da

Gene ID: 9099

UniProt: O75604