Integrin beta 7 antibody (C-Term)

Catalog No. ABIN2798921

The Rabbit Polyclonal anti-Integrin beta 7 antibody has been validated for WB. It is suitable to detect Integrin beta 7 in samples from Human.

Quick Overview for Integrin beta 7 antibody (C-Term) (ABIN2798921)

Target: Integrin beta 7 (ITGB7)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Integrin beta 7 Antibody

Binding Specificity: AA 737-765, C-Term

Purpose: Rabbit Anti-Human ITGB7 (C-term) Antibody

Immunogen: This ITGB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-765 amino acids from the C-terminal region of human ITGB7.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000ITGB7 Antibody (C-term) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Alternative Name: ITGB7

Background:

Target Description: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Gene Symbol: ITGB7

Molecular Weight: 86903 Da

Gene ID: 3695

UniProt: P26010

Pathways: Integrin Complex