SIGLEC6 antibody (N-Term)

Catalog No. ABIN2798979

This anti-SIGLEC6 antibody is a Rabbit Polyclonal antibody detecting SIGLEC6 in WB. Suitable for Human.

Quick Overview for SIGLEC6 antibody (N-Term) (ABIN2798979)

Target: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGLEC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIGLEC6 Antibody

Binding Specificity: AA 10-40, N-Term

Purpose: Rabbit Anti-Human SIGLEC6 (N-term) Antibody

Immunogen: This SIGLEC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-40 amino acids from the N-terminal region of human SIGLEC6.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000Western blot analysis of SIGLEC6 Antibody (N-term) was detected using the purified Pab.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.0 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for SIGLEC6

Target: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Alternative Name: SIGLEC6

Background:

Target Description: SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

Gene Symbol: SIGLEC6

Molecular Weight: 49913 Da

Gene ID: 946

UniProt: O43699