USP7 antibody (Center)

Catalog No. ABIN2799159

This anti-USP7 antibody is a Rabbit Polyclonal antibody detecting USP7 in WB. Suitable for Human.

Quick Overview for USP7 antibody (Center) (ABIN2799159)

Target: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-USP7 Antibody

Binding Specificity: AA 320-348, Center

Purpose: Rabbit Anti-Human USP7 (Center) Antibody

Immunogen: This USP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-348 amino acids from the Central region of human USP7.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000USP7 Antibody (Center) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.450 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for USP7

Target: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Alternative Name: USP7

Background:

Target Description: Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.

Gene Symbol: USP7

Molecular Weight: 128302 Da

Gene ID: 7874

UniProt: Q93009