DGAT2 antibody (AA 251-360) (AbBy Fluor® 594)

Catalog No. ABIN2812362

This Rabbit Polyclonal antibody specifically detects DGAT2 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for DGAT2 antibody (AA 251-360) (AbBy Fluor® 594) (ABIN2812362)

Target: DGAT2 (Diacylglycerol O-Acyltransferase 2 (DGAT2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DGAT2 antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DGAT2 Antibody (AbBy Fluor® 594)

Binding Specificity: AA 251-360

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DGAT2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DGAT2

Target: DGAT2 (Diacylglycerol O-Acyltransferase 2 (DGAT2))

Alternative Name: DGAT2

Background:

Synonyms: DGAT2, DGAT2_HUMAN, Diacylglycerol O acyltransferase like protein 2, Diacylglycerol O-acyltransferase 2, Diacylglycerol O-acyltransferase homolog 2 mouse, Diacylglycerol O-acyltransferase homolog 2, Diacylglycerol O-acyltransferase-like protein 2 isoform 1, Diglyceride acyltransferase 2, DKFZp686A15125, GS1999full, HMFN1045.

Background: Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism.

Gene ID: 84649

UniProt: Q96PD7