KLF4 antibody (N-Term)

Catalog No. ABIN389188

This Rabbit Polyclonal antibody specifically detects KLF4 in WB. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for KLF4 antibody (N-Term) (ABIN389188)

Target: KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB14261

Product Details anti-KLF4 Antibody

Binding Specificity: AA 20-53, N-Term

Specificity: This KLF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20~50 amino acids from the N-terminal region of human KLF4.

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This KLF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-53 AA from the N-terminal region of human KLF4.

Isotype: Ig Fraction

Application Details

Application Notes: WB = 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-KLF4 antibody (ABIN389188)

Xu, Sun, Zhang, Jiang, Zhang, Zhou, Ding, Hu, Yan: "MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4." in: Molecular and cellular endocrinology, Vol. 452, pp. 138-147, (2018) (PubMed).

Yan, Yu, Liu, Kang, Ma, Zhou: "MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4." in: Biochemical and biophysical research communications, Vol. 467, Issue 4, pp. 913-20, (2015) (PubMed).

Jumabay, Abdmaulen, Ly, Cubberly, Shahmirian, Heydarkhan-Hagvall, Dumesic, Yao, Boström: "Pluripotent stem cells derived from mouse and human white mature adipocytes." in: Stem cells translational medicine, Vol. 3, Issue 2, pp. 161-71, (2014) (PubMed).

Marini, Porcu, Asunis, Loi, Ristaldi, Porcu, Ikuta, Cao, Moi: "Regulation of the human HBA genes by KLF4 in erythroid cell lines." in: British journal of haematology, Vol. 149, Issue 5, pp. 748-58, (2010) (PubMed).

Target Details for KLF4

Target: KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))

Alternative Name: KLF4

Background: Kruppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells. KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.
Synonyms: Kruppel-like factor 4, EZF, GKLF

Molecular Weight: 50945 DA

Gene ID: 9314

NCBI Accession: NP_004226

Pathways: Peptide Hormone Metabolism, Stem Cell Maintenance