ADK antibody (C-Term)

Catalog No. ABIN2841255

This Rabbit Polyclonal antibody specifically detects ADK in WB and IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for ADK antibody (C-Term) (ABIN2841255)

Target: ADK (Adenosine Kinase (ADK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB05395

Product Details anti-ADK Antibody

Binding Specificity: AA 322-352, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ADK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-352 amino acids from the C-terminal region of human ADK.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ADK antibody (ABIN2841255)

Annes, Ryu, Lam, Carolan, Utz, Hollister-Lock, Arvanites, Rubin, Weir, Melton: "Adenosine kinase inhibition selectively promotes rodent and porcine islet ?-cell replication." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 10, pp. 3915-20, (2012) (PubMed).

Target Details for ADK

Target: ADK (Adenosine Kinase (ADK))

Alternative Name: ADK

Background: Adenosine kinase is an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.

Molecular Weight: 40545

Gene ID: 132

NCBI Accession: NP_001114, NP_001189378, NP_001189379, NP_006712

UniProt: P55263

Pathways: Ribonucleoside Biosynthetic Process