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Activin A Receptor Type IB/ALK-4 antibody (Activin A Receptor, Type IB) (AA 134-164) Primary Antibody

ACVR1B Reactivity: Human, Mouse FACS, WB Host: Rabbit Polyclonal RB03514 unconjugated
Catalog No. ABIN2841926
$156.20
Plus shipping costs $45.00
80 μL ABIN2841926
80 μL ABIN2841926
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  • Target
    Activin A Receptor Type IB/ALK-4 (ACVR1B)
    Binding Specificity
    • 14
    • 10
    • 9
    • 9
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 134-164
    Reactivity
    • 57
    • 39
    • 23
    • 1
    Human, Mouse
    Host
    • 63
    • 18
    • 3
    • 2
    Rabbit
    Clonality
    • 67
    • 19
    Polyclonal
    Conjugate
    • 40
    • 14
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Activin A Receptor Type IB/ALK-4 antibody is un-conjugated
    Application
    • 66
    • 48
    • 17
    • 13
    • 12
    • 12
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Western Blotting (WB)
    Predicted Reactivity
    Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Activin A Receptor Type IB (ACVR1B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human Activin A Receptor Type IB (ACVR1B).
    Clone
    RB03514
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    Activin A Receptor Type IB/ALK-4 (ACVR1B)
    Alternative Name
    Activin A Receptor Type IB (ACVR1B) (ACVR1B Antibody Abstract)
    Synonyms
    ACVR1B, alk4, skr2, alk-4, xalk4, actrib, acvrlk4, DKFZp469A1614, 6820432J04, ActR-IB, ActRIB, Acvrlk4, Alk4, SKR2, ACTRIB, ACVRLK4, ALK4, Skr2, axis, taram-a, tarama, wu:fb75f01, activin A receptor type 1B, Activin receptor type-1B, activin A receptor, type IB, activin A receptor, type 1B, activin A receptor type 1Ba, ACVR1B, acvr1b, acv1b, Acvr1b, acvr1ba
    Background
    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The gene for ACVR1B (activin A type IB receptor) is composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
    Molecular Weight
    56807
    Gene ID
    91
    NCBI Accession
    NP_004293, NP_064732, NP_064733
    UniProt
    P36896
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