NPPB antibody

Catalog No. ABIN2854787

The Rabbit Polyclonal anti-NPPB antibody has been validated for WB, IF and ICC. It is suitable to detect NPPB in samples from Human.

Quick Overview for NPPB antibody (ABIN2854787)

Target: NPPB (Natriuretic Peptide Precursor B (NPPB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPPB antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-NPPB Antibody

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to BNP (natriuretic peptide precursor B)
BNP antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human BNP. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for NPPB

Target: NPPB (Natriuretic Peptide Precursor B (NPPB))

Alternative Name: natriuretic peptide B

Background: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.

Cellular Localization: Secreted

Molecular Weight: 15 kDa

Gene ID: 4879

UniProt: P16860

Pathways: Hormone Activity