ARG2 antibody (Center)

Catalog No. ABIN2855753

The Rabbit Polyclonal anti-ARG2 antibody has been validated for WB, IHC (p) and IHC (fro). It is suitable to detect ARG2 in samples from Human. There are 2+ publications available.

Quick Overview for ARG2 antibody (Center) (ABIN2855753)

Target: ARG2 (Arginase, Type II (ARG2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARG2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ARG2 Antibody

Binding Specificity: Center

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Rabbit Polyclonal antibody to Arginase II (arginase, type II)
Arginase II antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human ARG2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: mouse kidney , 293T cytoplasm extract , NT2D1

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.32 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-ARG2 antibody (ABIN2855753)

Polis, Srikanth, Gurevich, Gil-Henn, Samson: "L-Norvaline, a new therapeutic agent against Alzheimer's disease." in: Neural regeneration research, Vol. 14, Issue 9, pp. 1562-1572, (2019) (PubMed).

Polis, Srikanth, Elliott, Gil-Henn, Samson: "L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer's Disease." in: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, Vol. 15, Issue 4, pp. 1036-1054, (2019) (PubMed).

Target Details for ARG2

Target: ARG2 (Arginase, Type II (ARG2))

Alternative Name: arginase 2

Background: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood, it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.

Cellular Localization: Mitochondrion

Molecular Weight: 39 kDa

Gene ID: 384

UniProt: P78540