CDON antibody (N-Term)

Catalog No. ABIN2856103

This Rabbit Polyclonal antibody specifically detects CDON in WB and IHC (p). It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for CDON antibody (N-Term) (ABIN2856103)

Target: CDON (Cell Adhesion Molecule-Related/down-Regulated By Oncogenes (CDON))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDON antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CDON Antibody

Binding Specificity: N-Term

Cross-Reactivity: Mouse (Murine), Cow (Bovine)

Cross-Reactivity (Details): Mouse (84 %), Bovine (85 %)

Characteristics: Rabbit Polyclonal antibody to CDO (Cdon homolog (mouse))
CDO antibody [N1N2], N-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human CDO. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Comment:

Positive Control: A431 , H1299 , HeLa , HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-CDON antibody (ABIN2856103)

Kim, Lee, Seppala, Cobourne, Kim: "Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration." in: Nature communications, Vol. 11, Issue 1, pp. 1994, (2020) (PubMed).

Lu, Chen, Tung, Chen, Pan, Chang, Cheng, Chen, Wang, Huang, Kang, Chang, Li, Chang, Shih, Lin, Kwan, Tsai: "Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice." in: Nature communications, Vol. 9, Issue 1, pp. 2498, (2019) (PubMed).

Target Details for CDON

Target: CDON (Cell Adhesion Molecule-Related/down-Regulated By Oncogenes (CDON))

Alternative Name: CDO

Background: CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII, see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM]

Cellular Localization: Membrane

Molecular Weight: 139 kDa

Gene ID: 50937

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Embryonic Body Morphogenesis