PGC antibody (AA 100-200)

Catalog No. ABIN3016695

This Rabbit Polyclonal antibody specifically detects PGC in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for PGC antibody (AA 100-200) (ABIN3016695)

Target: PGC (Pepsinogen C (PGC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PGC Antibody

Binding Specificity: AA 100-200

Sequence: PSVYCQSQAC TSHSRFNPSE SSTYSTNGQT FSLQYGSGSL TGFFGYDTLT VQSIQVPNQE FGLSENEPGT NFVYAQFDGI MGLAYPALSV DEATTAMQGM V

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Pepsinogen II (NP_001159896.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PGC

Target: PGC (Pepsinogen C (PGC))

Alternative Name: PGC

Background: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.,PGC,PEPC,PGII,gastricsin,Cancer,Tumor biomarkers,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,PGC

Molecular Weight: 34 kDa/42 kDa

Gene ID: 5225

UniProt: P20142