ADAMTS5 antibody (AA 731-930)

Catalog No. ABIN3016806

Product Details anti-ADAMTS5 Antibody

Target: ADAMTS5 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5))

Binding Specificity: AA 731-930

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAMTS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 731-930 of human ADAMTS5 (NP_008969.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ADAMTS5 antibody (ABIN3016806)

Si, Zeng, Liu, Zhou, Chen, Cheng, Lu, Shen: "Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats." in: Osteoarthritis and cartilage, Vol. 25, Issue 10, pp. 1698-1707, (2018) (PubMed).

Target Details for ADAMTS5

Target: ADAMTS5 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5))

Alternative Name: ADAMTS5 (ADAMTS5 Products)

Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.,ADAMTS5,ADAM-TS 11,ADAM-TS 5,ADAM-TS5,ADAMTS-11,ADAMTS-5,ADAMTS11,ADMP-2,ADAM-TS11,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,ADAM Protein Family,MMPs,Ubiquitin,ADAMTS5

Molecular Weight: 101 kDa

Gene ID: 11096

UniProt: Q9UNA0