DDIT3 antibody (C-Term)

Catalog No. ABIN3020710

This anti-DDIT3 antibody is a Rabbit Polyclonal antibody detecting DDIT3 in WB and IF. Suitable for Human. This Primary Antibody has been cited in 3+ publications.

Quick Overview for DDIT3 antibody (C-Term) (ABIN3020710)

Target: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDIT3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-DDIT3 Antibody

Binding Specificity: C-Term

Sequence: GRTRKRKQSG HSPARAGKQR MKEKEQENER KVAQLAEENE RLKQEIERLT REVEATRRAL IDRMVNLHQA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human DDIT3/CHOP (NP_004074.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-DDIT3 antibody (ABIN3020710)

Zhang, Yan, Wang, Dai, Wang, Cai: "Autophagy May Protect Against Parenteral Nutrition-Associated Liver Disease by Suppressing Endoplasmic Reticulum Stress." in: JPEN. Journal of parenteral and enteral nutrition, Vol. 43, Issue 1, pp. 96-106, (2019) (PubMed).

Anasa, Manickam, Talwar, Ravanan: "Identification of ASB7 as ER stress responsive gene through a genome wide in silico screening for genes with ERSE." in: PLoS ONE, Vol. 13, Issue 4, pp. e0194310, (2018) (PubMed).

Knowlton, Fernández de Castro, Ashbrook, Gestaut, Zamora, Bauer, Forrest, Frydman, Risco, Dermody: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).

Target Details for DDIT3

Target: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Alternative Name: DDIT3

Background: This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.,DDIT3,CEBPZ,CHOP,CHOP-10,CHOP10,GADD153,C/EBPzeta,DDIT3 / CHOP,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Protein folding,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Stem Cells,Embryonic Stem Cells,DDIT3

Molecular Weight: 19 kDa/21 kDa

Gene ID: 1649

UniProt: P35638

Pathways: Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis