IKKi/IKKe antibody (AA 495-716)

Catalog No. ABIN3020771

Product Details anti-IKKi/IKKe Antibody

Target: IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Binding Specificity: AA 495-716

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKKi/IKKe antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LRSRLRTLAE VLSRCSQNIT ETQESLSSLN RELVKSRDQV HEDRSIQQIQ CCLDKMNFIY KQFKKSRMRP GLGYNEEQIH KLDKVNFSHL AKRLLQVFQE ECVQKYQASL VTHGKRMRVV HETRNHLRLV GCSVAACNTE AQGVQESLSK LLEELSHQLL QDRAKGAQAS PPPIAPYPSP TRKDLLLHMQ ELCEGMKLLA SDLLDNNRII ERLNRVPAPP DV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 495-716 of human IKKepsilon (NP_054721.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-IKKi/IKKe antibody (ABIN3020771)

He, Ma, Tian, Wei, Zhu, Li, Zhang, Wang, Zhang, Zhong: "ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction." in: PLoS pathogens, Vol. 13, Issue 6, pp. e1006347, (2017) (PubMed).

Gao, Yang, Yuan, Huang, Xu, Mao, Yuan, Bi: "TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration." in: Oncogenesis, Vol. 6, Issue 9, pp. e383, (2017) (PubMed).

Target Details for IKKi/IKKe

Target: IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Alternative Name: IKBKE (IKBKE Products)

Background: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30 % of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009],IKBKE,IKK-E,IKK-i,IKKE,IKKI,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Death Receptor Signaling Pathway,Immunology & Inflammation,B Cell Receptor Signaling Pathway,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,IKBKE

Molecular Weight: 70 kDa/80 kDa

Gene ID: 9641

UniProt: Q14164

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades