CRADD antibody (AA 1-199)
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- Target See all CRADD Antibodies
- CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
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Binding Specificity
- AA 1-199
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CRADD antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
- Cross-Reactivity
- Human, Mouse
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAIDD/RAIDD/CRADD (NP_003796.1).
- Isotype
- IgG
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- Application Notes
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze / thaw cycles
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
- Alternative Name
- CRADD (CRADD Products)
- Synonyms
- cradd antibody, MGC89035 antibody, zgc:101717 antibody, CRADD antibody, DKFZp468A2219 antibody, LOC100226369 antibody, raidd antibody, MGC78788 antibody, MRT34 antibody, RAIDD antibody, CASP2 and RIPK1 domain containing adaptor with death domain antibody, CASP2 and RIPK1 domain containing adaptor with death, gene 1 antibody, CASP2 and RIPK1 domain containing adaptor with death, gene 2 S homeolog antibody, CRADD antibody, cradd.1 antibody, cradd antibody, cradd.2.S antibody, Cradd antibody
- Background
- This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.,CRADD,MRT34,RAIDD,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Death Receptor Signaling Pathway,CRADD
- Molecular Weight
- 11 kDa/22 kDa
- Gene ID
- 8738
- UniProt
- P78560
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity