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CRADD antibody (AA 1-199)
CRADD
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CRADD Antibody
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Target
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CRADD
(CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
Binding Specificity
All epitopes for CRADD antibodies
AA 1-199
Reactivity
All reactivities for CRADD antibodies
Human
Host
All hosts for CRADD antibodies
Rabbit
Clonality
All clonalities for CRADD antibodies
Polyclonal
Conjugate
All conjugates for CRADD antibodies
This CRADD antibody is un-conjugated
Application
All applications for CRADD antibodies
Western Blotting (WB)
Sequence
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
Cross-Reactivity
Human, Mouse
Characteristics
Polyclonal Antibodies
Purification
Affinity purification
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAIDD/RAIDD/CRADD (NP_003796.1).
Isotype
IgG
Top Product
Discover our top product CRADD Primary Antibody
Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid freeze / thaw cycles
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for CRADD
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Target
CRADD
(CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
Alternative Name
CRADD (CRADD Products )
Background
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.,CRADD,MRT34,RAIDD,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Death Receptor Signaling Pathway,CRADD
Molecular Weight
11 kDa/22 kDa
Gene ID
8738
UniProt
P78560
Pathways
Apoptosis , Caspase Cascade in Apoptosis , Positive Regulation of Endopeptidase Activity
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