CRADD antibody

Catalog No. ABIN7266106

This Rabbit Monoclonal antibody specifically detects CRADD in WB and IF. It exhibits reactivity toward Human.

Quick Overview for CRADD antibody (ABIN7266106)

Target: CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CRADD antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-CRADD Antibody

Purpose: RAIDD/CRADD Rabbit mAb

Cross-Reactivity: Human, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human RAIDD/CRADD

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CRADD

Target: CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))

Alternative Name: CRADD

Background: This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],MRT34, RAIDD,Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,Cancer,Cell Biology & Developmental Biology,Death Receptor Signaling Pathway,Invasion and Metastasis,CRADD

Molecular Weight: 23kDa

Gene ID: 8738

UniProt: P78560

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity