CD1b antibody

Catalog No. ABIN3026713

This anti-CD1b antibody is a Mouse Monoclonal antibody detecting CD1b in FACS, IF and Func. Suitable for Human.

Quick Overview for CD1b antibody (ABIN3026713)

Target: CD1b (CD1B)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD1b antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: RIV12

Product Details anti-CD1b Antibody

Characteristics: This antibody recognizes CD1b, a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1b molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. It is also expressed in interdigitating cells.

Purification: Protein G affinity chromatography

Immunogen: Human peripheral lymphocytes were used as the immunogen for this CD1b antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD1b antibody to be titered up or down for optimal performance.\. Functional testing: order BSA/azide free format,IF: 0.5-1 μg/mL,FACS: 0.5-1 μg/million cells in 0.1ml

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the CD1b antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for CD1b

Target: CD1b (CD1B)

Alternative Name: CD1b

Background: This antibody recognizes CD1b, a 44  kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1b molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. It is also expressed in interdigitating cells.

Gene ID: 910