CD1d antibody (AA 76-92)

Catalog No. ABIN3030370

This Rabbit Polyclonal antibody specifically detects CD1d in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for CD1d antibody (AA 76-92) (ABIN3030370)

Target: CD1d (CD1D) (CD1d Molecule (CD1D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD1d antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CD1d Antibody

Binding Specificity: AA 76-92

Purification: Antigen affinity

Immunogen: Amino acids 76-92 (FSDQQWETLQHIFRVYR-human) were used as the immunogen for this CD1d antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the CD1d antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CD1d antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CD1d

Target: CD1d (CD1D) (CD1d Molecule (CD1D))

Alternative Name: CD1d

Background: CD1d is the sole group-2 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production. Jayawardena-Wolf et al. described 2 different pathways of CD1d trafficking to endosomal compartments in mouse cells. A tyrosine-based motif governs recycling between the plasma membrane and the endosome, while CD1d associates, like major histocompatibility complex class II antigens, with the invariant chain, or II, in the endoplasmic reticulum. Both pathways enhance antigen presentation to CD1d-restricted natural killer T cells.

UniProt: P15813

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process