MOAP1 antibody (Center)

Catalog No. ABIN303284

The Rabbit Polyclonal anti-MOAP1 antibody has been validated for WB and IHC (p). It is suitable to detect MOAP1 in samples from Human and Mouse.

Quick Overview for MOAP1 antibody (Center) (ABIN303284)

Target: MOAP1 (Modulator of Apoptosis 1 (MOAP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MOAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MOAP1 Antibody

Binding Specificity: Center

Specificity: This antibody recognises MAP-1 Protein (MOAP1).

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic Peptide corresponding to 15 amino acid peptide from near the center of human MAP-1.

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Western Blot (1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer. Dilute only prior to immediate use.

Target Details for MOAP1

Target: MOAP1 (Modulator of Apoptosis 1 (MOAP1))

Alternative Name: MOAP1

Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.Synonyms: MAP-1, MAP1, Modulator of apoptosis 1

Gene ID: 64112

NCBI Accession: NP_071434

UniProt: Q96BY2

Pathways: Positive Regulation of Endopeptidase Activity