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FOSB antibody (C-Term)

This anti-FOSB antibody is a Rabbit Polyclonal antibody detecting FOSB in WB, IHC and FACS. Suitable for Human, Mouse and Rat.
Catalog No. ABIN3042399

Quick Overview for FOSB antibody (C-Term) (ABIN3042399)

Target

See all FOSB Antibodies
FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB))

Reactivity

  • 70
  • 32
  • 15
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Mouse, Rat

Host

  • 64
  • 6
Rabbit

Clonality

  • 55
  • 15
Polyclonal

Conjugate

  • 37
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This FOSB antibody is un-conjugated

Application

  • 49
  • 18
  • 15
  • 14
  • 13
  • 4
  • 4
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
  • Binding Specificity

    • 19
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 264-291, C-Term

    Purpose

    Anti-Fos B/FOSB Antibody Picoband®

    Sequence

    LPFQTSQDAP PNLTASLFTH SEVQVLGD

    Cross-Reactivity (Details)

    No cross-reactivity with other proteins

    Characteristics

    Anti-Fos B/FOSB Antibody (ABIN3042399). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Purification

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human Fos B, different from the related mouse sequence by two amino acids.

    Isotype

    IgG
  • Application Notes

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Kelz, M. B., Chen, J., Carlezon, W. A., Jr., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., Tkatch, T., Baranauskas, G., Surmeier, D. J., Neve, R. L., Duman, R. S., Picciotto, M. R., Nestler, E. J.Expression of the transcription factor delta-FosB in the brain controls sensitivity to cocaine.Nature 401: 272-276, 1999. 2. Martin-Gallardo, A., McCombie, W. R., Gocayne, J. D., FitzGerald, M. G., Wallace, S., Lee, B. M. B., Lamerdin, J., Trapp, S., Kelley, J. M., Liu, L.-I., Dubnick, M., Johnston-Dow, L. A., Kerlavage, A. R., de Jong, P., Carrano, A., Fields, C., Venter, J. C.Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3.Nature Genet. 1: 34-39, 1992. 3. Nakabeppu, Y., Nathans, D.A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity.Cell 64: 751-759, 1991.

    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Concentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freezing and thawing.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB))

    Alternative Name

    FOSB

    Background

    Synonyms: Protein fosB,G0/G1 switch regulatory protein 3,FOSB,G0S3,

    Tissue Specificity: Testis-specific. Expressed in prostate cancer (at protein level). .

    Background: FOSB, FBJ murine osteosarcoma viral oncogene homolog B, is a protein that, in humans, is encoded by the FOSB gene. FOSB is a member of Fos gene family which consists of 4 members: FOS, FOSB, < a href="https://www.bosterbio.com/anti-fra1-fosl1-mouse-monoclonal-antibody-clone-id-oti12f9-m03927-boster.html" style="color:#EA8D28">FOSL1, and FOSL2. The FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. The FOSB gene is mapped to 19q13.32. Delta FOSB is a truncated splice variant of FOSB. Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain, and is linked to changes in a number of other gene products such as CREB and sirtuins. Delta FosB also regulates the commitment of mesenchymal precursor cells to the adipocyte or osteoblast lineage.

    Sequence Similarities: Belongs to the bZIP family. Fos subfamily.

    Molecular Weight

    35 kDa

    Gene ID

    2354

    UniProt

    P53539
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