FOXM1 antibody (AA 411-763)

Catalog No. ABIN3042402

Product Details anti-FOXM1 Antibody

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Binding Specificity: AA 411-763

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXM1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Forkhead box protein M1(FOXM1) detection. Tested with WB in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Forkhead box protein M1(FOXM1) detection. Tested with WB in Human.
Gene Name: forkhead box M1
Protein Name: Forkhead box protein M1

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FOXM1 recombinant protein (Position: A411-Q763). Human FOXM1 shares 75% and 76% amino acid (aa) sequences identity with mouse and rat FOXM1, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for FOXM1 is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for FOXM1

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Alternative Name: FOXM1 (FOXM1 Products)

Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.

Synonyms: FKHL16 antibody|Forkhead box M1 antibody|Forkhead box protein M1 antibody|forkhead like 16 antibody|Forkhead-related protein FKHL16 antibody|FOX M1 antibody|Foxm1 antibody|FOXM1_HUMAN antibody|FOXM1B antibody|Hepatocyte nuclear factor 3 forkhead homolog 11 antibody|HFH-11 antibody|HFH11 antibody|HNF-3/fork-head homolog 11 antibody|HNF3 antibody|INS1 antibody|M phase phosphoprotein 2 antibody|M-phase phosphoprotein 2 antibody|MPHOSPH2 antibody|MPM 2 antibody|MPM-2 reactive phosphoprotein 2 antibody|MPM2 reactive phosphoprotein 2 antibody|MPP2 antibody|PIG29 antibody|TGT3 antibody|Transcription factor Trident antibody|Trident antibody|WIN antibody|Winged-helix factor from INS-1 cells antibody|Winged-helix factor from INS1 cells antibody

Gene ID: 2305

UniProt: Q08050

Pathways: Positive Regulation of Response to DNA Damage Stimulus