HDAC7 antibody (N-Term)

Catalog No. ABIN3042441

This anti-HDAC7 antibody is a Rabbit Polyclonal antibody detecting HDAC7 in WB. Suitable for Human and Rat.

Quick Overview for HDAC7 antibody (N-Term) (ABIN3042441)

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HDAC7 Antibody

Binding Specificity: AA 68-103, N-Term

Purpose: Anti-HDAC7 Antibody Picoband®

Sequence: QLLHKDKSKR SAVASSVVKQ KLAEVILKKQ QAALER

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-HDAC7 Antibody Picoband® (ABIN3042441). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human HDAC7, different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Rat
1. "Entrez Gene: HDAC7A histone deacetylase 7A". 2. Kao HY, Downes M, Ordentlich P, Evans RM (Jan 2000). "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression". Genes & Development 14 (1): 55-66. 3. Marks PA, Richon VM, Rifkind RA (Aug 2000). "Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells". Journal of the National Cancer Institute 92 (15): 1210-6.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for HDAC7

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Alternative Name: HDAC7

Background:

Synonyms: Histone deacetylase 7,HD7,3.5.1.98,Histone deacetylase 7A,HD7a,HDAC7,HDAC7A,

Tissue Specificity: Liver.

Background: Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. It is mapped to 12q13.1. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation / deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Sequence Similarities: Contains 1 HMG box DNA-binding domain.

Molecular Weight: 103 kDa

Gene ID: 51564

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development