KLF6 antibody (AA 38-205)

Catalog No. ABIN3042475

This Rabbit Polyclonal antibody specifically detects KLF6 in WB. It exhibits reactivity toward Human and Rat.

Quick Overview for KLF6 antibody (AA 38-205) (ABIN3042475)

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KLF6 Antibody

Binding Specificity: AA 38-205

Purpose: Anti-KLF6 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-KLF6 Antibody (ABIN3042475). Tested in WB applications. This antibody reacts with Human, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human KLF6 recombinant protein (Position: E38-N205). Human KLF6 shares 92% and 90% amino acid (aa) sequences identity with mouse and rat KLF6, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Rat

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for KLF6

Target: KLF6 (Kruppel-Like Factor 6 (KLF6))

Alternative Name: KLF6

Background:

Synonyms: Krueppel-like factor 6,B-cell-derived protein 1,Core promoter element-binding protein,GC-rich sites-binding factor GBF,Proto-oncogene BCD1,Suppressor of tumorigenicity 12 protein,Transcription factor Zf9,KLF6,BCD1, COPEB, CPBP, ST12,

Tissue Specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.

Background: Krueppel-like factor 6 (KLF6) is a protein that in humans is encoded by the KLF6 gene. It is a tumor suppressor gene which is located on 10p15.1. This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.

Sequence Similarities: Belongs to the krueppel C2H2-type zinc-finger protein family.

Molecular Weight: 37 kDa

Gene ID: 1316

UniProt: Q99612