PTOV1 antibody (C-Term)

Catalog No. ABIN3042495

This anti-PTOV1 antibody is a Rabbit Polyclonal antibody detecting PTOV1 in WB. Suitable for Human and Rat.

Quick Overview for PTOV1 antibody (C-Term) (ABIN3042495)

Target: PTOV1 (Prostate Tumor Overexpressed 1 (PTOV1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTOV1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PTOV1 Antibody

Binding Specificity: AA 385-414, C-Term

Purpose: Anti-PTOV1 Antibody Picoband®

Sequence: NFVNGIRRVI ANQQQVLQRN LEQEQQQRGM

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-PTOV1 Antibody (ABIN3042495). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PTOV1, different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Rat, Human
1. "Entrez Gene: PTOV1 prostate tumor overexpressed gene 1". 2. Santamaria A, Castellanos E, Gomez V, Benedit P, Renau-Piqueras J, Morote J, Reventos J, Thomson TM, Paciucci R (Feb 2005). "PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts". Mol Cell Biol 25 (5): 1900-11. 3. Santamaria A, Fernandez PL, Farre X, Benedit P, Reventos J, Morote J, Paciucci R, Thomson TM (Feb 2003)."PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle". Am J Pathol 162 (3): 897-905.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for PTOV1

Target: PTOV1 (Prostate Tumor Overexpressed 1 (PTOV1))

Alternative Name: PTOV1

Background:

Synonyms: Prostate tumor-overexpressed gene 1 protein,PTOV-1,Activator interaction domain-containing protein 2,PTOV1,ACID2,PP642, UNQ6127/PRO20092,

Tissue Specificity: Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine. .

Background: Prostate tumor overexpressed gene 1 protein is a protein that in humans is encoded by the PTOV1 gene. It is mapped to 19q13.33. This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants.

Sequence Similarities: Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.

Molecular Weight: 47 kDa

Gene ID: 53635