CREB3L1 antibody (AA 1-204)

Catalog No. ABIN3042759

This anti-CREB3L1 antibody is a Rabbit Polyclonal antibody detecting CREB3L1 in WB. Suitable for Human.

Quick Overview for CREB3L1 antibody (AA 1-204) (ABIN3042759)

Target: CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB3L1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CREB3L1 Antibody

Binding Specificity: AA 1-204

Purpose: Anti-CREB3L1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-CREB3L1 Antibody Picoband® (ABIN3042759). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CREB3L1 recombinant protein (Position: M1-M204). Human CREB3L1 shares 93.6% and 93.1% amino acid (aa) sequence identity with mouse and rat CREB3L1, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Denard B, Lee C, Ye J. ""Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1"". Elife, 2012 Dec 18. 2. Mellor P, Deibert L, Calvert B, Bonham K, Carlsen SA, Anderson DH. ""CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis"". Mol Cell Biol, 2013 Dec.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for CREB3L1

Target: CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))

Alternative Name: CREB3L1

Background:

Synonyms: Cyclic AMP-responsive element-binding protein 3-like protein 1,cAMP-responsive element-binding protein 3-like protein 1,Old astrocyte specifically-induced substance,OASIS,Processed cyclic AMP-responsive element-binding protein 3-like protein 1,CREB3L1,OASIS,PSEC0238,

Tissue Specificity: Expressed in several tissues, with highest levels in pancreas and prostate. Expressed at relatively lower levels in brain. .

Background: CREB3L1, known as Cyclic AMP-responsive element-binding protein 3-like protein 1, is mapped to 11p11.2. The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements.

Sequence Similarities: Belongs to the bZIP family. ATF subfamily.

Molecular Weight: 57 kDa

Gene ID: 90993

Pathways: Thyroid Hormone Synthesis, Chromatin Binding