CCR9 antibody (N-Term)

Catalog No. ABIN3042897

This anti-CCR9 antibody is a Rabbit Polyclonal antibody detecting CCR9 in WB. Suitable for Human.

Quick Overview for CCR9 antibody (N-Term) (ABIN3042897)

Target: CCR9 (Chemokine (C-C Motif) Receptor 9 (CCR9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR9 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CCR9 Antibody

Binding Specificity: AA 1-17, N-Term

Purpose: Anti-C-C chemokine receptor type 9 CCR9 Antibody Picoband®

Sequence: MTPTDFTSPI PNMADDY

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-C-C chemokine receptor type 9 CCR9 Antibody (ABIN3042897). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CCR9.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Eksteen, B., Grant, A. J., Miles, A., Curbishley, S. M., Lalor, P. F., Hubscher, S. G., Briskin, M., Salmon, M., Adams, D. H. Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis. J. Exp. Med. 200: 1511-1517, 2004. 2. Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M., von Andrian, U. H. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 424: 88-93, 2003. 3. Papadakis, K. A., Prehn, J., Nelson, V., Cheng, L., Binder, S. W., Ponath, P. D., Andrew, D. P., Targan, S. R. The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. J. Immun. 165: 5069-5076, 2000. 4. Wendland, M., Czeloth, N., Mach, N., Malissen, B., Kremmer, E., Pabst, O., Forster, R. CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc. Nat. Acad. Sci. 104: 6347-6352, 2007.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CCR9

Target: CCR9 (Chemokine (C-C Motif) Receptor 9 (CCR9))

Alternative Name: CCR9

Background:

Synonyms: C-C chemokine receptor type 9,C-C CKR-9,CC-CKR-9,CCR-9,G-protein coupled receptor 28,GPR-9-6,CDw199,CCR9,GPR28,

Tissue Specificity: Highly expressed in the thymus and low in lymph nodes and spleen. .

Background: C-C chemokine receptor type 9, also called GPR-9-6 or CDw199, is a protein that in humans is encoded by the CCR9 gene. The protein encoded by this gene is a member of the beta chemoking receptor family. By radiation hybrid analysis and organization of BAC contigs by FISH on combed genomic DNA, the CCR9 gene within the CCR cluster was localized at 3p21.3. It is the receptor for chemokine SCYA25/TECK. This gene subsequently transduces a signal by increasing the intracellular calcium ions level. It is an alternative coreceptor with CD4 for HIV-1 infection. This gene may play a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract.

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Molecular Weight: 42 kDa

UniProt: P51686