STRAP antibody (N-Term)

Catalog No. ABIN3043302

This anti-STRAP antibody is a Rabbit Polyclonal antibody detecting STRAP in WB and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for STRAP antibody (N-Term) (ABIN3043302)

Target: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRAP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-STRAP Antibody

Binding Specificity: AA 78-104, N-Term

Purpose: Anti-Unrip/STRAP Antibody Picoband®

Sequence: AADFTAKVWD AVSGDELMTL AHKHIVK

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Unrip/STRAP Antibody Picoband® (ABIN3043302). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Unrip, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Datta PK, Chytil A, Gorska AE, Moses HL (December 1998). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling". J. Biol. Chem. 273 (52): 34671-4. 2. Grimmler, M., Otter, S., Peter, C., Muller, F., Chari, A., Fischer, U. Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. Hum. Molec. Genet. 14: 3099-3111, 2005.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for STRAP

Target: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Alternative Name: STRAP

Background:

Synonyms: Serine-threonine kinase receptor-associated protein,MAP activator with WD repeats,UNR-interacting protein,WD-40 repeat protein PT-WD,STRAP,MAWD, UNRIP,

Tissue Specificity: Ubiquitously expressed in various human primary cells and tumor cell lines. .

Background: Unrip is also known as STRAP (Serine-threonine kinase receptor-associated protein). It is anenzyme that in humans is encoded by the STRAP gene. It is mapped to 12p12.3. UNRIP is integrated into a complex with UNR or with the SMN complex in vivo in a mutually exclusive manner. It is concluded that UNRIP is the first component of the uridine-rich snRNP assembly machinery that associates with the SMN complex in a compartment-specific way, and it may play a crucial role in the intracellular distribution of the SMN complex.

Sequence Similarities: Belongs to the WD repeat STRAP family.

Molecular Weight: 39 kDa

Gene ID: 11171

UniProt: Q9Y3F4