SHBG antibody (AA 30-210)

Catalog No. ABIN3043434

Product Details anti-SHBG Antibody

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Binding Specificity: AA 30-210

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHBG antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Sex hormone-binding globulin(SHBG) detection. Tested with WB in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Sex hormone-binding globulin(SHBG) detection. Tested with WB in Human.
Gene Name: sex hormone-binding globulin
Protein Name: Sex hormone-binding globulin

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SHBG recombinant protein (Position: L30-A210). Human SHBG shares 72% amino acid (aa) sequence identity with both mouse and rat SHBG.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for SHBG is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for SHBG

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Alternative Name: SHBG (SHBG Products)

Background: Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones,androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta. SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.

Synonyms: ABP antibody|Androgen binding protein antibody|SBP antibody|Sex hormone-binding globulin antibody|Sex steroid binding protein antibody|Sex steroid-binding protein antibody|SHBG antibody|SHBG_HUMAN antibody|TeBG antibody|Testis specific androgen binding protein antibody|Testis-specific androgen-binding protein antibody|Testosterone binding beta globulin antibody|Testosterone estradiol binding globulin antibody|Testosterone estrogen binding globulin antibody|Testosterone-estradiol-binding globulin antibody|Testosterone-estrogen-binding globulin antibody

Gene ID: 6462

UniProt: P04278

Pathways: Hormone Transport