Somatostatin antibody (C-Term)

Catalog No. ABIN3044066

The Rabbit Polyclonal anti-Somatostatin antibody has been validated for WB and IHC. It is suitable to detect Somatostatin in samples from Human, Mouse and Rat. There are 5+ publications available.

Quick Overview for Somatostatin antibody (C-Term) (ABIN3044066)

Target: Somatostatin (SST)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Somatostatin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Somatostatin Antibody

Binding Specificity: AA 89-107, C-Term

Purpose: Anti-Somatostatin/SST Antibody Picoband®

Sequence: SANSNPAMAP RERKAGCKN

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Somatostatin/SST Antibody (ABIN3044066). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Somatostatin, identical to the related rat and mouse sequences.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Rat, Human, Mouse
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Naylor, S. L., Sakaguchi, A. Y., Shen, L.-P., Bell, G. I., Rutter, W. J., Shows, T. B. Polymorphic human somatostatin gene is located on chromosome 3. Proc. Nat. Acad. Sci. 80: 2686-2689, 1983. 2. Saito, T., Iwata, N., Tsubuki, S., Takaki, Y., Takano, J., Huang, S.-M., Suemoto, T., Higuchi, M., Saido, T. C. Somatostatin regulates brain amyloid beta-peptide A-beta-42 through modulation of proteolytic degradation. Nature Med. 11: 434-439, 2005. 3. Yacubova, E., Komuro, H. Stage-specific control of neuronal migration by somatostatin. Nature 415: 77-81, 2002.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-Somatostatin antibody (ABIN3044066)

Mao, Lu, Wang, Tian, Huang, Feng, Zhang, Chang: "Role of PI3K p110β in the differentiation of human embryonic stem cells into islet-like cells." in: Biochemical and biophysical research communications, Vol. 488, Issue 1, pp. 109-115, (2017) (PubMed).

Wang, Zhou, Zhang, Wu, Zhang, Zhang: "Identification and localization of gastrointestinal hormones in the skin of the bullfrog Rana catesbeiana during periods of activity and hibernation." in: Acta histochemica, Vol. 116, Issue 8, pp. 1418-26, (2014) (PubMed).

Chen, He, Peng, Liu, Jin, Cao, Wang, Xiao: "An immunohistochemical study of somatostatin in the stomach and the small intestine of the African ostrich (Struthio camelus)." in: Tissue & cell, Vol. 45, Issue 6, pp. 363-6, (2013) (PubMed).

Jiang, Deng, Duan, Chen, Xiang, Lu, Ma: "Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct." in: Lymphology, Vol. 44, Issue 1, pp. 21-8, (2011) (PubMed).

Zong, Chen, Zhang, Zou: "Effects of intra-gastric beta-casomorphin-7 on somatostatin and gastrin gene expression in rat gastric mucosa." in: World journal of gastroenterology, Vol. 13, Issue 14, pp. 2094-9, (2007) (PubMed).

Target Details for Somatostatin

Target: Somatostatin (SST)

Alternative Name: SST

Target Type: Chemical

Background:

Synonyms: Somatostatin,Growth hormone release-inhibiting factor,Somatostatin-28,Somatostatin-14,SST,

Tissue Specificity: Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. .

Background: SST (Somatostatin), also known as SMST, is a peptide hormone. Naylor et al. (1983) assigned the somatostatin gene to chromosome 3 by analyzing somatic cell hybrids with a polymorphic gene probe. Yacubova and Komuro (2002) examined the effects of somatostatin in cerebellar granule cells of early postnatal mice, because these cells express all 5 types of somatostatin receptors before the initiation of their migration. Saito et al. (2005) found that somatostatin modulated the proteolytic degradation of beta-amyloid catalyzed by neprilysin both in vitro and in vivo.

Sequence Similarities: Belongs to the somatostatin family.

Molecular Weight: 83 kDa

UniProt: P61278