S1PR4 antibody (C-Term)

Catalog No. ABIN306931

This Mouse Monoclonal antibody specifically detects S1PR4 in FACS. It exhibits reactivity toward Human.

Quick Overview for S1PR4 antibody (C-Term) (ABIN306931)

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This S1PR4 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 1

Product Details anti-S1PR4 Antibody

Binding Specificity: C-Term

Isotype: IgG1

Application Details

Application Notes: Antibody can be used for flow cytometry (use 1 ug of antibody per 106 cells). NOTE: Epitope for the antibody is the C-terminal of the EDG6 protein. The C-terminal is an intracellular region and cells need to be permeablized prior to staining with antibody.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/ml

Storage: 4 °C

Target Details for S1PR4

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Alternative Name: Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6) FITC Conjugate

Background: EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG6 (S1P4) receptor is the sphingosine 1-phosphate receptor-4 (S1P4). Synonyms: Endothelial cell differentiation gene 6 C-terminal, Sphingosine-1-Phosphate Receptor-4 (S1P4).